解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::N-Methyl-3-phenyl-norbornan-2-amine (N-methyl-3-phenylbicyclo[2.2.1]heptan-2-amine, Camfetamine(™) ) is available from a number of online legal highs/research chemicals' vendors. Although it was developed as an analeptic by Merck in the early 1960s, it was never commercialized. However, the Association of Independent ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.411
更新日期:2013-04-01 00:00:00
abstract::A new, simple, rapid, accurate and precise high performance thin layer chromatography (HPTLC) method has been developed for the estimation of ondansetron hydrochloride in bulk and sublingual tablets. The mobile phase composition was chloroform : ethyl acetate : methanol : ammonia (9:5:4:0.1 v/v). Spectrodensitometric ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.311
更新日期:2013-02-01 00:00:00
abstract::Addiction is a complex disorder with interacting factors, including environmental factors, drug-induced neurobiological changes, comorbidity, personality traits and stress responsivity. Numerous genetic variants that affect these factors may work in concert to affect vulnerability and severity of addiction. Traditiona...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1401
更新日期:2013-01-01 00:00:00
abstract::The purpose of this research is to validate the biomarker-based approach for the detection of doping with recombinant human growth hormone (rhGH) in sport. The GH-2000 project proposed an indirect method for the detection of exogenously administered growth hormone (GH) based on the measurement of the GH-dependent mark...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1423
更新日期:2012-10-01 00:00:00
abstract::Synthetic cannabinoids are the psychotropic compounds frequently identified as active components of smoking mixtures easily available via the Internet in several countries. These herbal blends have become extremely popular as a legal alternative to cannabis-based products and are difficult to detect by regular drug te...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1418
更新日期:2012-10-01 00:00:00
abstract::Prenylamine is a vasodilator of phenylalkylamine structure and was used for the treatment of angina pectoris, until reports of undesirable effects including ventricular tachycardia led to a decreasing use of the drug in the 1980s. Metabolic N-dealkylation of orally ingested prenylamine can liberate amphetamine in huma...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1388
更新日期:2012-09-01 00:00:00
abstract::A new and sensitive multi-residue method (MRM) with detection by LC-MS/MS was developed and validated for the screening, determination, and confirmation of residues of 7 nitroimidazoles and 3 of their metabolites in turkey muscle tissues at concentrations ≥ 0.05 ng/g. The compounds were extracted into a solvent with a...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1356
更新日期:2012-08-01 00:00:00
abstract::Detection of the abuse of synthetic steroids in food production is nowadays relatively straightforward using modern techniques such as gas or liquid chromatography coupled to mass spectrometry (GC-MS/MS or LC-MS/MS, respectively). However, proving the abuse of 'endogenous' (or naturally occurring) steroids is more dif...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.1354
更新日期:2012-08-01 00:00:00
abstract::Two primary animal models persist for assessing hallucinogenic potential of novel compounds and for examining the pharmacological and neurobiological substrates underlying the actions of classical hallucinogens, the two-lever drug discrimination procedure and the drug-induced head-twitch response (HTR) in rodents. The...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.1333
更新日期:2012-07-01 00:00:00
abstract::A series of regioisomeric bromodimethoxyamphetamines have mass spectra essentially equivalent to the controlled drug substance 4-Br-2,5-dimethoxyamphetamine (4-Br-2,5-DMA; DOB); all have molecular weight of 274 and major fragment ions in their electron ionization mass spectra at m/z 44 and m/z 230/232. The trifluoroac...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.409
更新日期:2012-07-01 00:00:00
abstract::The consumption of drugs is of great concern worldwide. Various drug tests for humans have been developed but there is no compact and easy-to-use test device available yet for direct semi-quantitative drug testing in the field. We suggest using attenuated total reflection (ATR) infrared spectroscopy as a sensing metho...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.346
更新日期:2012-06-01 00:00:00
abstract::Standard treatment of poisoning by organophosphorus (OP) nerve agents with atropine and oximes lacks efficacy with some nerve agents. Promising in vitro and in vivo results were obtained with the bispyridinium compound SAD-128 which was partly attributed to its interaction with nicotinic acetylcholine receptors. Previ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.410
更新日期:2012-03-01 00:00:00
abstract::MSforID represents a database of tandem mass spectral data obtained from (quasi-)molecular ions produced by atmospheric pressure ionization methods. At the current stage of development the library contains 12 122 spectra of 1208 small (bio-)organic molecules. The present work was aimed to evaluate the performance of t...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.341
更新日期:2012-03-01 00:00:00
abstract::Fast and unequivocal drug detection is of considerable importance in numerous fields of analytical chemistry, and today mass spectrometry-based approaches are often the method of choice due to their sensitive and specific nature. Mass spectrometry is in constant flux with innovations and thus supports the development ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.344
更新日期:2012-03-01 00:00:00
abstract::Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Being the key target of OP toxicity, AChE may serve as a valuable tool for diagnosis of OP exposure as well as for the invest...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.337
更新日期:2012-03-01 00:00:00
abstract::The quantitative structure-property relationship (QSPR) of drug molecules against the immobilized liposome chromatography partitioning (log K(s)) was studied. The genetic algorithm (GA) was employed to select the variables that resulted in the best-fitted models. After the variables were selected, the linear multivari...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.262
更新日期:2012-02-01 00:00:00
abstract::Workplace drug testing in Europe is governed by a patchwork of legislation--or lack of it. Other difficulties are caused by language, currency and a host of other factors, including the difficulty in defining 'safety critical'. The European Workplace Drug Testing Society's (EWDTS) history and objectives are briefly ou...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.1326
更新日期:2012-02-01 00:00:00
abstract::The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proacti...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.398
更新日期:2012-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are small, non-protein coding transcripts involved in many cellular and physiological mechanisms. Recently, a new class of miRNA called 'circulating miRNAs' was found in cell-free body fluids such as plasma and urine. Circulating miRNAs have been shown to be very stable, specific, and sensitive biom...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.370
更新日期:2011-11-01 00:00:00
abstract::The advent of liquid chromatography-tandem mass spectrometry (LC-MS/MS), with the sensitivity it confers, permits the analysis of both phase I and II drug metabolites that in the past would have been difficult to target using other techniques. These metabolites may have relevance to current analytical toxicology emplo...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.305
更新日期:2011-10-01 00:00:00
abstract::A simple, sensitive, and selective spectrophotometric method has been developed for the determination of gabapentin (GBP) in capsules. The method is based on the reaction of GBP and sodium 1,2-naphthoquinone-4-sulfonate (NQS) in the presence of Clark and Lubs buffer of pH 11 to form an orange-coloured product which wa...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.242
更新日期:2011-10-01 00:00:00
abstract::The Ministry of Health in the Netherlands has made illicit drug testing for drug users possible since the 1990s, in order to prevent serious health hazards associated with unexpected dangerous substances. This system of illicit drug testing is called the Drug Information and Monitoring System (DIMS). In nearly two dec...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.323
更新日期:2011-09-01 00:00:00
abstract::Designer drugs belong to a group of legally or illegally produced substances that are structurally and pharmacologically very similar to illicit drugs. In the past, designer drugs were often used during all-night dance parties, but they are now consumed in multiple settings from college bars to parks to private house ...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.210
更新日期:2011-09-01 00:00:00
abstract::Abuse of gamma-hydroxybutyric acid (GHB) has been known since the early 1990's, but is not as widespread as the consumption of other illegal drugs. However, the number of severe intoxications with fatal outcomes is comparatively high; not the least of which is brought about by the consumption of the currently legal pr...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.254
更新日期:2011-09-01 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) has been used as a recreational drug since the 1990s and over the last few years there has been increasing use of its analogues gamma-butyrolactone (GBL) and to a lesser extent 1,4-butanediol (1,4BD). This review will summarize the literature on the pharmacology of these compounds; the patt...
journal_title:Drug testing and analysis
pub_type: 杂志文章,评审
doi:10.1002/dta.292
更新日期:2011-07-01 00:00:00
abstract::A novel poly (vinyl chloride) PVC membrane sensor for Fe(2+) ions is described. The sensor is based on the use of newly synthesized chiral 2,6-bis-(carboxamide methyl ester)pyridine derivative as neutral ionophore in plasticized PVC membrane. The sensor display a fast, stable and near-Nernstian response over a relativ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.231
更新日期:2011-06-01 00:00:00
abstract::The accuracy in predicting different chemometric methods was compared when applied on ordinary UV spectra and first order derivative spectra. Principal component regression (PCR) and partial least squares with one dependent variable (PLS1) and two dependent variables (PLS2) were applied on spectral data of pharmaceuti...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.235
更新日期:2011-05-01 00:00:00
abstract::Erythropoietin (EPO) has been misused in sports for many years due to its performance-enhancing effect. In the last decade, detection of abuse has been possible with isoelectric focusing (IEF) based on the different isoform profiles of endogenous and recombinant EPO. The release of new EPOs on the market, such as the ...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.270
更新日期:2011-05-01 00:00:00
abstract::The method of high sensitive gas chromatographic/time-of-flight mass-spectrometric (GC/TOF-MS) analysis of steroids was developed. Low-resolution TOF-MS instrument (with fast spectral acquisition rate) was used. This method is based on the formation of the silyl derivatives of steroids; exchange of the reagent mixture...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.221
更新日期:2011-04-01 00:00:00
abstract::Different extracts of Nigella sativa L. seed waste; aqueous (AE) 200 mg/kg, ethanol 70% (EE) 250 mg/kg and hexane (HE) 10 mg/kg, were evaluated for their hepatoprotective activities. They were administered orally, once daily, for 5 consecutive days. On day 5, liver injury was induced in animals by a single i.p. inject...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.225
更新日期:2011-04-01 00:00:00
abstract::A simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi-wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT-modified GCE exhibite...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.205
更新日期:2011-03-01 00:00:00
abstract::In this tutorial we describe the construction of chemiluminescence detectors for high performance liquid chromatography (HPLC), comprising the components required to deliver the chemiluminescence reagent, a coiled-tubing flow cell, photomultiplier tube and detector housing, and various options for data acquisition. We...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.132
更新日期:2011-03-01 00:00:00
abstract::The second programme of its kind globally, the highly successful, collaborative, productive and energizing IFDAT-International Forum for Drug and Alcohol Testing, was held in Barcelona, Spain, from 12-14 April. IFDAT was attended by over 100 delegates, conference sponsors and exhibitors from the international workplac...
journal_title:Drug testing and analysis
pub_type:
doi:10.1002/dta.150
更新日期:2011-03-01 00:00:00
abstract::The objective of the present work was (1) to develop an in situ gelling ophthalmic delivery system by combining pluronic F127 and pluronic F68, with sparfloxacin; and (2) to examine the influence of incorporating a mucoadhesive polysaccharide such as sodium hyaluronate on the healing property due to bacterial keratiti...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.170
更新日期:2011-02-01 00:00:00
abstract::Detection of androgenic-anabolic steroid abuse in equine sports requires knowledge of the drug's metabolism in order to target appropriate metabolites, especially where urine is the matrix of choice. Studying 'designer' steroid metabolism is problematic since it is difficult to obtain ethical approval for in vivo meta...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.250
更新日期:2011-01-01 00:00:00
abstract::Doping with natural steroids can be detected by evaluating the urinary concentrations and ratios of several endogenous steroids. Since these biomarkers of steroid doping are known to present large inter-individual variations, monitoring of individual steroid profiles over time allows switching from population-based to...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.206
更新日期:2010-11-01 00:00:00
abstract::Selective androgen receptor modulators (SARMs) have great therapeutic potential in various diseases including cancer cachexia, sarcopenia, and osteoporosis, and the number of drug candidates has been growing over the last decade. The SARM drug candidates S-22 and S-23 belong to one of the most advanced groups of andro...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.211
更新日期:2010-11-01 00:00:00
abstract::Trimethoprim (TMP) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Its use is associated with idiosyncratic reactions, including liver toxicity and agranulocytosis. I...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.161
更新日期:2010-09-01 00:00:00
abstract::Drug and alcohol abuse is a concern for many European companies, especially those having safety-critical jobs. It is not uncommon for European companies to establish a drug policy with little or no provision for drug testing. The European Union (EU) has launched a number of initiatives in its fight against drugs. Ther...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.147
更新日期:2010-08-01 00:00:00
abstract::Three sensitive, selective and precise stability-indicating methods for the determination of the anti-Alzheimer's drug, rivastigmine hydrogen tartrate (RIV) in the presence of its alkaline degradation product (major metabolite, NAP 226-90) and in pharmaceutical formulation were developed and validated. The first metho...
journal_title:Drug testing and analysis
pub_type: 杂志文章
doi:10.1002/dta.121
更新日期:2010-05-01 00:00:00